The digital transformation of the public sector and the development of suitable implementation mechanisms are currently major challenges in the area of E-Government. While Germany is one of the leading countries in the private sector in terms of digital offerings, the digital transformation processes in the public sector are progressing only slowly. In particular, compared to other European countries, German administrations offer few digital and interoperable services, which prevents them from catching up with a government-wide dig-ital transformation. The aim of this dissertation is to investigate the reasons for the slow progress of digital transformation in the public sector and to understand why Germany is not making significant progress in the digitization of administrative services compared to other European member states. Furthermore, it aims to gradually build a comprehensive understanding of why digital transformation is not being driven, supported or applied in the public sector and what positive or negative factors ultimately prevent cross-organizational exchange. The focus of this dissertation is on organizational and interdisciplinary collaboration in socio-technical systems and its influence on the digital transformation of public administrations. The investigation of science and practice is based on the principles of qualitative social research and qualitative content analysis according to Mayring. Deductive categories are systematically derived and supplemented by further inductive categories along the empirical investigation in the five case studies. The identified phenomena are analyzed in a scientific explanatory model and described with the help of the holistic approach and the actor-network theory. On this basis, solutions are developed that can either prevent or at least reduce the influencing factors. An interdiscipli-nary approach that combines theoretical foundations from business informatics, administrative informatics/e-government and organizational science not only creates a comprehensive understanding of the problem, but also develops approaches for the scientific description of informatics phenomena with the help of social constructivist approaches.